NCAA Football Best Games Week 4

There is no shortage of excitement on the Week 4 FBS college football schedule, including the James Madison Dukes playing the North Carolina Tar Heels.

Here’s everything you need to know about
the betting odds for Week 4 in college football.

Below you’ll find our betting primers for this season, and find all of our expert predictions here, too!

Week 4’s Best College Football Games

James Madison (3-0) at North Carolina (3-1)

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  • Game Time: 12:00 PM ET | Saturday, September 21, 2024
  • Venue: Kenan Stadium
  • Location: Chapel Hill, North Carolina
Odds to Cover

North Carolina -10.5 vs. James Madison

Bet $20, Payout $37.09

No. 6 Tennessee (3-0) at No. 15 Oklahoma (3-0)

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  • Game Time: 7:30 PM ET | Saturday, September 21, 2024
  • Venue: Gaylord Family Oklahoma Memorial Stadium
  • Location: Norman, Oklahoma
Spread

Tennessee -6.5 vs. Oklahoma

Bet $20, Payout $38.35

No. 11 USC (2-1) at No. 18 Michigan (3-1)

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  • Game Time: 3:30 PM ET | Saturday, September 21, 2024
  • Venue: Michigan Stadium
  • Location: Ann Arbor, Michigan
To Cover the Spread

USC -4.5 vs. Michigan

Bet $20, Payout $38.18

No. 13 Kansas State (3-0) at BYU (3-0)

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  • Game Time: 10:30 PM ET | Saturday, September 21, 2024
  • Venue: LaVell Edwards Stadium
  • Location: Provo, Utah
Odds to Cover

Kansas State -7 vs. BYU

Bet $20, Payout $38.35

Louisiana-Monroe (2-0) at No. 1 Texas (3-0)

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  • Game Time: 8:00 PM ET | Saturday, September 21, 2024
  • Venue: DKR-Texas Memorial Stadium
  • Location: Austin, Texas
Odds to Cover

Texas -43.5 vs. Louisiana-Monroe

Bet $20, Payout $38.35

Georgia Southern (2-1) at No. 5 Ole Miss (3-0)

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  • Game Time: 7:45 PM ET | Saturday, September 21, 2024
  • Venue: Vaught-Hemingway Stadium
  • Location: Oxford, Mississippi
Spread

Ole Miss -35.5 vs. Georgia Southern

Bet $20, Payout $38.02

TCU (2-2) at SMU (3-1)

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  • Game Time: 5:00 PM ET | Saturday, September 21, 2024
  • Venue: Gerald J. Ford Stadium
  • Location: University Park, Texas
Spread

TCU -1.5 vs. SMU

Bet $20, Payout $38.35

Rutgers (3-0) at Virginia Tech (2-2)

  • Game Time: 3:30 PM ET | Saturday, September 21, 2024
  • Venue: Lane Stadium
  • Location: Blacksburg, Virginia

UCLA (1-2) at No. 16 LSU (3-1)

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  • Game Time: 3:30 PM ET | Saturday, September 21, 2024
  • Venue: Tiger Stadium
  • Location: Baton Rouge, Louisiana
Odds to Cover

LSU -21.5 vs. UCLA

Bet $20, Payout $38.18

Marshall (1-2) at No. 3 Ohio State (3-0)

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  • Game Time: 12:00 PM ET | Saturday, September 21, 2024
  • Venue: Ohio Stadium
  • Location: Columbus, Ohio
Betting Odds

Ohio State -39.5 vs. Marshall

Bet $20, Payout $37.70