Cardinals vs. Guardians Betting Odds, Pitching Matchup – September 22, 2024

The Cleveland Guardians (90-66) serve as underdogs on the moneyline (-109) in Sunday’s contest with the St. Louis Cardinals (78-77). First pitch is at 2:15 p.m. ET on BSGL. The Guardians are favored against the spread in this one (1.5) with +166 odds. St. Louis’ Andre Pallante gets the start, and he’ll go against Cleveland’s Gavin Williams.

Check out our betting primer for this contest, and find all of our expert MLB picks, too!

Odds to Win

Cardinals to win vs Guardians -111

Bet $20, Payout $38.02

Cardinals vs. Guardians Betting Lines

  • Favorite: Cardinals (-111)
  • Underdog: Guardians (-109)
  • Over/under: 7.5

Cardinals vs. Guardians Betting Insights

  • The Cardinals have been chosen as favorites in 73 games this year and have walked away with the win 37 times (50.7%) in those games.
  • St. Louis has a record of 37-36 in contests when oddsmakers favor them by -111 or more on the moneyline.
  • Bookmakers have implied with the moneyline set for this matchup that the Cardinals have a 52.6% chance of pulling out a win.
  • The Guardians have gone 27-30 in games they were the underdog on the moneyline (winning 47.4% of those games).
  • Cleveland has gone 27-30 when it has played as a moneyline underdog with odds of -109 or longer (47.4%).
  • The implied moneyline probablility in this matchup gives the Guardians a 52.2% chance to win.

Cardinals vs. Guardians Hitting Leaders

  • Brendan Donovan leads St. Louis with a batting average of .273. He’s also hit 13 home runs with 68 RBI.
  • Donovan’s home runs rank him 145th in Major League Baseball, and he is 71st in RBI.
  • Alec Burleson is batting .269 this season with a team-high 21 home runs and 73 RBI.
  • Jose Ramirez leads the Guardians with 37 home runs and 112 runs batted in.
  • In all of MLB, Ramirez is seventh in homers and third in RBI.
  • Josh Naylor has 26 doubles, 31 home runs and 56 walks while hitting .241.

Cardinals vs. Guardians Pitching Rankings

  • The Cardinals average just 8.2 strikeouts per nine innings as a pitching staff, which ranks 26th in the league.
  • The Cardinals have the 16th-ranked ERA (4.08) in the majors this season.
  • Cardinals pitchers have a 1.263 WHIP this season, 18th in the majors.
  • The Guardians pitching staff is eighth in MLB with a collective 8.9 strikeouts per nine innings.
  • Cleveland has a 3.65 team ERA that ranks third among all MLB pitching staffs.
  • Pitchers for the Guardians combine for the No. 3-ranked WHIP in the majors (1.201).