49ers vs. Rams Betting in NJ: Odds, Betting Line and Spread

The San Francisco 49ers (1-1) have a division matchup with the Los Angeles Rams (0-2) on Sunday at SoFi Stadium.

The 49ers are 6.5-point favorites against the Rams. The over/under is set at 43.5 points.

Here is our betting preview for this contest, and uncover all of our expert NFL picks, too!

Betting Odds

49ers to win vs Rams -289

Bet $20, Payout $26.92

49ers vs. Rams Betting Information

  • Spread favorite: 49ers (-6.5)
  • Moneyline: 49ers (-289), Rams (+234)
  • Total: 43.5 points
  • TV Channel: FOX
  • Live Stream: Fubo (Watch for free)

49ers vs. Rams Betting Insights

In two games, the 49ers have won just once against the spread. The 49ers have been favored twice and split the two games. Away from home, the 49ers’ record is 0-1 (and against the spread they are 0-1). The Rams are winless in two games against the spread. The Rams have been underdogs in one game, and lost.

49ers vs. Rams Stats Insights

49ers Stats

  • The 49ers are averaging nine fewer points per game (24.5) than the Rams are allowing (33.5).
  • The Rams’ defense has given up an average of 426 yards per game in 2024, a total of 27.5 yards more than the 398.5 the 49ers’ offense has averaged. The 49ers pick up 6.1 yards per play and the Rams give up 7.1.

Rams Stats

  • The Rams have averaged six fewer points per game (15) than the 49ers have allowed (21).
  • The Rams’ offense has averaged 316 yards per game this season, within 18.5 yards of the 334.5 the 49ers’ defense has allowed. The Rams pick up 5.3 yards per play and the 49ers give up 6.7.

49ers vs. Rams Leaders

49ers

  • Jordan Mason (RB): 247 YDS / 2 TD / 123.5 YPG / 5.1 YPC
  • Brock Purdy (QB): 550 YDS (72.3%) / 1 TD / 1 INT / 23 RUSH YDS / 0 RUSH TD / 11.5 RUSH YPG
  • Deebo Samuel (WR): 13 REC / 164 YDS / 0 TD / 82 YPG
  • George Kittle (TE): 11 REC / 116 YDS / 1 TD / 58 YPG
  • Fred Warner (LB): 16 TKL / 1 TFL / 1 SACK / 1 INT

Rams

  • Matthew Stafford: 533 PASS YDS / 266.5 YPG / 69.7% / 1 TD / 1 INT
  • Kyren Williams: 30 CAR / 75 YDS / 37.5 YPG / 2 TD / 7 REC / 31 YDS / 15.5 YPG / 0 TD
  • Blake Corum: 8 CAR / 28 YDS / 14 YPG / 0 TD
  • Cooper Kupp: 18 REC / 147 YDS / 73.5 YPG / 1 TD
  • Tyler Johnson: 7 REC / 99 YDS / 49.5 YPG / 0 TD