The Louisville Cardinals (3-0) will take on the Notre Dame Fighting Irish (3-1) on Saturday at 3:30 p.m. ET.
The Cardinals are underdogs, but by less than a touchdown (+6.5), against the Fighting Irish (with an over/under of 45.5 points).
Below you can find our betting preview for this season, and find all of our predictions here, too!
Notre Dame -6.5 vs. Louisville
Notre Dame vs. Louisville Betting Odds
- Spread favorite: Fighting Irish (-6.5)
- Moneyline: Fighting Irish (-255), Cardinals (+204)
- Total: 45.5 points
Notre Dame vs. Louisville Betting Stats and Info
The Fighting Irish’s record against the spread is only 2-2-0. In three tries when favored by 6.5 points or more, the Fighting Irish have beaten the spread just once. Notre Dame has been listed the moneyline favorite three times this season, and has put up a 2-1 record in those outings. Louisville, in two games with a spread so far this season, is unbeaten (2-0-0) against the spread. Louisville has not played a game as an underdog on the moneyline so far this season.
Notre Dame vs. Louisville Key Players
Notre Dame Fighting Irish
- This season Riley Leonard has put up 587 passing yards (146.8 YPG) while completing 63.1% of his passes, with one touchdown and two interceptions. He also has 322 rushing yards on 46 attempts (plus six scores), averaging 80.5 yards per game.
- Jeremiyah Love has taken 46 attempts for a team-high 339 rushing yards (84.8 YPG) and four touchdowns.
- Beaux Collins has 16 receptions for a team-high 176 yards (44 per game) and one touchdown.
- Jaden Greathouse has also contributed with nine catches for 79 yards. He has been targeted 13 times and averages 19.8 receiving yards per game.
- Jayden Harrison is averaging 17.5 yards per game, racking up seven receptions (eight targets) for 70 yards.
- Boubacar Traore has collected a team-leading three sacks, while adding four TFL, 10 tackles, and one interception.
- Jack Kiser has collected 20 tackles, and he’s tops on his team in tackles.
- Christian Gray has picked off one pass to lead the team while adding five tackles and one pass defended.
Louisville Cardinals
- This season, Tyler Shough has collected 850 passing yards (283.3 per game) while connecting on 52 of 76 passes (68.4%), with eight touchdowns and zero interceptions.
- Isaac Brown has run for a team-high 173 yards on 16 carries (57.7 yards per game) and one touchdown.
- Duke Watson has run for 141 yards on 12 carries (47 yards per game), with two touchdowns on the ground.
- Ja’Corey Brooks has racked up 17 catches for 297 yards, best on his team, and two touchdowns. He averages 99 receiving yards per game.
- Chris Bell has hauled in six catches for 167 yards (55.7 per game) and two touchdowns.
- Jadon Thompson has caught six passes on seven targets for 88 yards and two touchdowns.
- This season Tramel Logan leads the team with three sacks and has added two TFL and three tackles.
- Over the course of the current campaign, Stanquan Clark has totaled seven tackles and leads the team in tackles.
- T.J. Capers has a team-high one interception and has tacked on one pass defended in three games this season.