LSU vs. USC Spread, Line, Odds and Betting Preview | September 1

The USC Trojans are in action on Sunday at 7:30 p.m. ET at Allegiant Stadium against the LSU Tigers.

The Tigers are favored, but by less than a touchdown (-4.5), versus the Trojans. The over/under for this matchup is 66.5 points.

Keep reading for our betting primer for this season, and discover all of our betting picks here, too!

Betting Odds

LSU -4.5 vs. USC

Bet $20, Payout $38.69

LSU vs. USC Betting Odds

  • Spread favorite: Tigers (-4.5)
  • Moneyline: Tigers (-185), Trojans (+153)
  • Total: 66.5 points
  • TV Channel: ABC
  • Live Stream: Fubo (Watch for free)

LSU vs. USC Betting Stats and Info

  • LSU won six games against the spread last season, failing to cover six times.
  • LSU was 6-3 ATS last season when playing as at least 4.5-point favorites.
  • Last season, the combined scoring went over the point total 11 times in LSU games.
  • USC won four games against the spread last year, failing to cover nine times.
  • USC covered the spread when playing as at least 4.5-point underdogs in two of two opportunities last year.
  • In USC games last season, combined scoring went over the point total 10 times.

LSU vs. USC Key Players

LSU Tigers

  • Jayden Daniels threw for 3,813 yards (293.3 per game) while completing 72.2% of his passes (236-for-327), with 40 touchdowns and four interceptions last season. He also carried the ball 135 times for 1,134 yards and 10 touchdowns, averaging 87.2 yards per game.
  • Last year Logan Diggs ran for 653 yards on 119 carries (50.2 yards per game), with seven rushing touchdowns.
  • Last year Malik Nabers was targeted 130 times and amassed 89 catches for 1,569 yards with 14 touchdowns.
  • Brian Thomas Jr. also added 1,177 receiving yards on 68 catches and 17 touchdowns. He was targeted 90 times, and put up 90.5 yards per game.
  • Kyren Lacy caught 30 passes on 44 targets for 558 yards and seven touchdowns, averaging 42.9 yards per game.
  • Last season, Harold Perkins totaled 5.5 sacks, 9.0 TFL, 72 tackles, and one interception.
  • Major Burns’ 2023 campaign saw him total 88 tackles, 3.0 TFL, one sack, and one interception.
  • Andre Sam intercepted three passes while adding 78 tackles and three passes defended a season ago.

USC Trojans

  • Caleb Williams threw for 3,633 yards while completing 68.4% of his passes last season, with 30 touchdowns and five interceptions (279.5 yards per game).
  • MarShawn Lloyd ran for 820 yards on 116 attempts (63.1 yards per game) and scored nine touchdowns a season ago. He also averaged 17.8 receiving yards per game, grabbing 13 passes for 232 yards.
  • Last year Austin Jones ran for 477 yards on 85 carries (36.7 yards per game), with seven rushing touchdowns.
  • Tahj Washington grabbed 59 passes for 1,062 yards last season while scoring eight touchdowns. He was targeted 77 times, and averaged 81.7 yards per game.
  • Brenden Rice tacked on 791 yards on 45 catches and 12 touchdowns. He was targeted 70 times, and averaged 60.8 receiving yards last season.
  • Duce Robinson totaled 351 yards on 16 catches with two touchdowns in 2023.
  • Jamil Muhammad put together a strong body of work a year ago, notching 6.5 sacks, 8.0 TFL and 43 tackles.
  • Mason Cobb totaled 82 tackles and 5.0 TFL over the course of his 2023 campaign.
  • Chris Roland-Wallace picked off two passes and tacked on 35 tackles, 3.0 TFL, and two passes defended last season.