Louisville vs. Jacksonville State Spread, Line, Odds and Betting Preview | Sept. 7

The Louisville Cardinals (1-0) are in action on Saturday at 3:30 p.m. ET versus the Jacksonville State Gamecocks (0-1) at L&N Federal Credit Union Stadium.

The Gamecocks are expected to lose by at least two TDs (currently +28.5) against the Cardinals (with an over/under of 56.5 points).

Keep reading for our betting preview for this season, and uncover all of our expert picks here, too!

Odds to Cover

Louisville -28.5 vs. Jacksonville State

Bet $20, Payout $38.02

Louisville vs. Jacksonville State Betting Odds

  • Spread favorite: Cardinals (-28.5)
  • Moneyline: Cardinals (-8333), Gamecocks (+1913)
  • Total: 56.5 points

Louisville vs. Jacksonville State Betting Stats and Info

  • Louisville put together a 6-7-1 record against the spread last season.
  • Louisville covered the spread when playing as at least 28.5-point favorites in its only opportunity last season.
  • Last season, the combined scoring went over the point total seven times in Louisville games.
  • Jacksonville State put together a 7-4-0 record against the spread last season.
  • Last season, five Jacksonville State games went over the point total.

Louisville vs. Jacksonville State Key Players

Louisville Cardinals

  • Jack Plummer threw for 3,204 yards last season (228.9 per game) while completing 64.8% of his passes (256-for-395), with 21 touchdowns and 12 interceptions.
  • A season ago Jawhar Jordan churned out 1,128 rushing yards (80.6 per game) and scored 13 touchdowns. He tacked on 21 catches for 246 yards and one receiving touchdown.
  • Isaac Guerendo amassed 810 rushing yards on 132 carries, with 11 touchdowns on the ground, last year. He also caught 22 passes for 234 yards.
  • Last season Jamari Thrash grabbed 63 passes for 858 yards (61.3 per game) and scored six touchdowns.
  • Chris Bell added 407 receiving yards on 29 catches and two touchdowns. He was targeted 44 times, and put up 29.1 yards per game.
  • Kevin Coleman Jr. totaled 362 receiving yards on 26 catches with two TDs.
  • Ashton Gillotte had a strong body of work a year ago, collecting 11 sacks, 10 TFL and 45 tackles.
  • TJ Quinn’s 2023 campaign saw him total 88 tackles, 0.5 sacks, and one interception.
  • Devin Neal picked off four passes while adding 73 tackles, two TFL, and four passes defended a season ago.

Jacksonville State Gamecocks

  • Zion Webb threw for 1,437 yards while completing 50.5% of his passes with six touchdowns and eight interceptions last season. He also carried the ball 132 times for 708 yards and seven scores.
  • Malik Jackson ran for 897 yards on 146 attempts (69 yards per game) and scored seven touchdowns a season ago.
  • Last season Perry Carter Jr. was targeted 68 times and had 38 catches for 672 yards with four touchdowns.
  • Quinton Lane’s stat line last season was 30 grabs for 342 yards and one touchdown. He put up 26.3 receiving yards per game.
  • Sean Brown collected 294 yards on 19 catches with five touchdowns in 2023.
  • Chris Hardie put together an impressive body of work a year ago, registering 8.5 sacks, 15 TFL, 60 tackles, and one interception.
  • Over the course of his 2023 campaign, Quae Drake racked up 92 tackles, four TFL, two sacks, and one interception.
  • Kekoura Tarnue intercepted three passes while adding 52 tackles, two TFL, one sack, and four passes defended a season ago.