Guardians vs. Astros Betting Odds, Pitching Matchup – September 29, 2024

The Cleveland Guardians (92-69) host the Houston Astros (88-73) at 3:10 p.m. ET Sunday for a sluggers’ duel between two of the best home-run hitters in baseball. Jose Ramirez has racked up 39 homers this season (No. 5 in the league) for the favored Guardians which sit as -184 favorites, while Yordan Alvarez ranks 10th in the majors with 35 dingers of his own for the underdogs. Nick Sandlin will get the ball for Cleveland while Houston will counter with Ryan Gusto.

Be sure to check out our betting preview for this game, and discover all of our MLB picks, too!

Guardians vs. Astros Betting Lines

• Favorite: Guardians (-184)
• Underdog: Astros (+153)
• Over/under: 7.5

Guardians vs. Astros Betting Insights

• The Guardians have won in 65, or 64.4%, of the 101 contests they have been named as odds-on favorites in this year.
• Cleveland has a record of 10-6 when favored by -184 or more this year.
• The moneyline set for this matchup implies the Guardians have a 64.8% chance of coming away with a victory in the contest.
• The Astros have put together a 21-23 record in games they were the underdog on the moneyline (winning 47.7% of those games).
• Houston has played as a moneyline underdog of +153 or longer in just one game this season, which it lost.
• The Astros have an implied moneyline win probability of 39.5% in this game.

Guardians vs. Astros Hitting Leaders

• Ramirez leads Cleveland in home runs with 39 and runs batted in with 118.
• Ramirez’s home runs put him fifth in baseball, and he is third in RBI.
• Josh Naylor has 137 hits and an OBP of .320 to go with a slugging percentage of .456 this season.
• Alvarez paces the Astros in home runs (35), runs batted in (86) and has put up a team-high batting average of .308.
• Alvarez’s home run total ranks 10th in the majors, and he is 31st in RBI.
• Jose Altuve has 31 doubles, 20 home runs and 47 walks while hitting .295.

Guardians vs. Astros Pitching Rankings

• The Guardians strike out 8.9 batters per nine innings as a pitching staff, eighth-best in MLB.
• The Guardians have pitched to a 3.61 ERA this season, which ranks fourth in baseball.
• The Guardians have a combined 1.202 WHIP as a pitching staff, third-lowest in MLB.
• The 9.3 strikeouts per nine innings put together by the Astros pitching staff ranks third in MLB.
• Houston has the sixth-ranked team ERA across all MLB pitching staffs (3.74).
• The Astros have the 13th-ranked WHIP in the majors (1.246).