Louisville vs. SMU Spread, Line, Odds and Betting Preview | Oct. 5

Star wide receiver RJ Maryland and the SMU Mustangs (4-1) play the Louisville Cardinals (3-1) on Saturday at 12:00 p.m. ET at L&N Federal Credit Union Stadium.

The Cardinals are the favorites (-6.5) in their game versus the Mustangs, with the over/under being 56 points. (In terms of the moneyline, the Cardinals are -251 and the Mustangs are +201.)

Keep reading for our betting preview for this season, and uncover all of our betting picks here, too!

Betting Odds

Louisville -6.5 vs. SMU

Bet $20, Payout $37.24

Louisville vs. SMU Betting Odds

  • Spread favorite: Cardinals (-6.5)
  • Moneyline: Cardinals (-251), Mustangs (+201)
  • Total: 56 points
  • TV Channel: ESPN
  • Live Stream: Fubo (Watch for free)

Louisville vs. SMU Betting Stats and Info

The Cardinals’ record against the spread is just 2-1-0. The Cardinals’ record against the spread, when favored by 6.5 points or more, is a spotless 2-0. Louisville has won both games as a moneyline favorite this season. SMU, in four games with a set spread so far this season, is 2-2-0 against the spread. SMU has been listed as the underdog on the moneyline once so far this season, and won that game.

Louisville vs. SMU Recent Stats and Trends

Louisville Cardinals

SMU Mustangs

Louisville vs. SMU Key Players

Louisville Cardinals

  • Tyler Shough has posted 1,114 passing yards (278.5 per game) with a 65% completion percentage (76-for-117) while firing 11 touchdowns and one interception. He also has 51 rushing yards via 12 attempts.
  • Isaac Brown has rushed for a team-best 245 yards (61.3 per game) and one touchdown.
  • So far this year Keyjuan Brown has rushed for 149 yards (37.3 per game), with two touchdowns.
  • Ja’Corey Brooks has 22 catches (on 31 targets) and leads the team with 368 receiving yards (92.0 per game) while hauling in four touchdowns.
  • Chris Bell has nine catches for 188 yards (47.0 per game) and two touchdowns.
  • Jamari Johnson has caught seven passes on 12 targets for 102 yards.
  • This season Tramel Logan leads the team with 3.0 sacks and has added 2.0 TFL and four tackles.
  • Stanquan Clark has racked up 13 tackles and 1.0 TFL to lead the team in tackles so far.
  • This season T.J. Capers leads the team with one interception and has added one pass defended.

SMU Mustangs

  • Kevin Jennings has thrown for 733 yards while completing 63.4% of his passes, with six touchdowns and one interception (146.6 yards per game). He also has 34 carries for 149 yards and one touchdown.
  • Brashard Smith has racked up a team-high 506 rushing yards (101.2 per game) and scored seven touchdowns. He has tacked on 11 catches for 121 yards, with one receiving touchdown.
  • Maryland has been targeted 22 times and has 16 catches, leading his team with 221 yards (44.2 per game) while hauling in three touchdowns.
  • Jake Bailey has been targeted 25 times, and chipped in with 170 yards (on 11 catches) and one touchdown.
  • This season Isaiah Smith leads the team with 2.5 sacks and has added 3.0 TFL and 11 tackles.
  • Kobe Wilson’s 31 tackles, 1.0 TFL, and two interceptions make him the team’s top tackler.
  • Ahmaad Moses has intercepted three passes to lead the team while adding 21 tackles, 1.0 TFL, and three passes defended.