Padres vs. White Sox Betting Odds, Pitching Matchup – September 21, 2024

The San Diego Padres (87-66) and Manny Machado (2 HR in his last game) are favored (-276) on the moneyline for their matchup with the Chicago White Sox (36-117) on Saturday at 8:40 p.m. ET on NBCS-CHI. Martin Perez will get the ball for San Diego while Chicago will counter with Chris Flexen.

Be sure to check out our preview for this contest, and find all of our expert MLB picks, too!

Padres vs. White Sox Betting Lines

• Favorite: Padres (-276)
• Underdog: White Sox (+225)
• Over/under: 8

Padres vs. White Sox Betting Insights

• The Padres have been chosen as favorites in 99 games this year and have walked away with the win 58 times (58.6%) in those games.
• San Diego has played as a favorite of -276 or more just one time this year and came away with a loss in that game.
• The moneyline set for this matchup implies the Padres have a 73.4% chance of walking away with the win.
• The White Sox have won 22.1% of the games this season they were the moneyline underdog (32-113).
• When it has played as a moneyline underdog with odds of +225 or longer, Chicago has gone 4-17 (19%).
• The White Sox have a 30.8% chance to win this contest based on the moneyline’s implied probability.

Padres vs. White Sox Hitting Leaders

• Jurickson Profar has been key for San Diego with 23 home runs, 83 RBI and a batting average of .283 this season.
• Profar’s home runs rank him 44th in MLB, and he ranks 34th in RBI.
• Machado is batting .279 this season with a team-high 29 home runs and 104 RBI.
• Andrew Vaughn has accumulated a team-best batting average of .247, and paces the White Sox in home runs (19) and runs batted in (67).
• Vaughn ranks 81st in home runs and 74th in RBI among all hitters in MLB.
• Andrew Benintendi’s 19 home runs pace his team.

Padres vs. White Sox Pitching Rankings

• The Padres strike out 9.1 batters per nine innings as a pitching staff, fourth-best in MLB.
• The Padres have the 12th-ranked ERA (3.89) in the majors this season.
• Padres pitchers have a 1.224 WHIP this season, eighth-best in the majors.
• The 8.6 strikeouts per nine innings compiled by the White Sox pitching staff ranks 15th in the majors.
• Chicago has a 4.80 team ERA that ranks 28th across all MLB pitching staffs.
• The White Sox have the second-highest WHIP in baseball (1.448).